Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair
نویسندگان
چکیده
منابع مشابه
Olfactory ensheathing cells and spinal cord repair.
The olfactory ensheathing cell is a specialized glial cell that assists in growth of the axons of the olfactory sensory neurons as they are generated and regenerated throughout adult life. There is increasing evidence in animal models that transplantation of olfactory ensheathing cell promotes recovery after transplantation into the injured spinal cord. Olfactory ensheathing cell transplants ha...
متن کاملUnderstanding the neural repair-promoting properties of olfactory ensheathing cells.
Olfactory ensheathing glial cells (OECs) are a specialized type of glia that form a continuously aligned cellular pathway that actively supports unprecedented regeneration of primary olfactory axons from the periphery into the central nervous system. Implantation of OECs stimulates neural repair in experimental models of spinal cord, brain and peripheral nerve injury and delays disease progress...
متن کاملComparative gene expression profiling of olfactory ensheathing glia and Schwann cells indicates distinct tissue repair characteristics of olfactory ensheathing glia.
Olfactory ensheathing glia (OEG) are a specialized type of glia that support the growth of primary olfactory axons from the neuroepithelium in the nasal cavity to the brain. Transplantation of OEG in the injured spinal cord promotes sprouting of injured axons and results in reduced cavity formation, enhanced axonal and tissue sparing, remyelination, and angiogenesis. Gene expression analysis ma...
متن کاملObtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS?
extraordinary regenerative properties of the peripheral olfactory system, and the role played by olfactory ensheath-ing cells (OEC), have been known for many years (Doucette, 1990). However, until recently this niche of neurobiology remained relatively obscure, attracting the attention of an enthusiastic, but relatively small band of scienti®c devotees. The OEC's sudden rise to prominence has h...
متن کاملCrucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts.
Olfactory ensheathing cells, the glial cells of the olfactory nervous system, exhibit unique growth-promoting and migratory properties that make them interesting candidates for cell therapies targeting neuronal injuries such as spinal cord injury. Transplantation of olfactory cells is feasible and safe in humans; however, functional outcomes are highly variable with some studies showing dramati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2019
ISSN: 2041-4889
DOI: 10.1038/s41419-019-1887-4